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Results for "

RNA polymerase-IN-1

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

2

Natural
Products

1

Click Chemistry

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128917
    DNA31

    		DNA/RNA Synthesis Infection
    DNA31 is a potent RNA polymerase inhibitor .
    DNA31
  • HY-163015
    RNA polymerase-IN-1

    		Others Infection
    RNA polymerase-IN-1 (compound 4) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-1 inhibits CYP isozymes .
    <em>RNA</em> <em>polymerase-IN-1</em>
  • HY-149050
    Viral polymerase-IN-1 hydrochloride

    		Influenza Virus SARS-CoV Infection
    Viral polymerase-IN-1 hydrochloride, a Gemcitabine (HY-17026) derivative, potently inhibits influenza A and B viruses infection with IC90 values of 11.4-15.9 μM. Viral polymerase-IN-1 hydrochloride is active against SARS-CoV-2 infection. Viral polymerase-IN-1 hydrochloride suppresses influenza virus infection by affecting viral RNA replication/transcription in cells .
    Viral <em>polymerase</em>-IN-1 hydrochloride
  • HY-147916
    RNA polymerase II-IN-1

    		DNA/RNA Synthesis Cancer
    RNA polymerase II-IN-1 (compound 19iv) is a amatoxin, inhibiting RNA polymerase II (Pol II) with an IC50 value of 36.66 nM. RNA polymerase II-IN-1 has higher cytotoxicity against cancer cells and less toxic in normal cells than α-Amanitin .
    RNA <em>polymerase</em> II-IN-1
  • HY-N12691
    Antiviral agent 51

    		Dengue virus Infection
    Antiviral agent 51 (compound a) is a potent antiviral agent. Antiviral agent 51 is a fucoidan. Antiviral agent 51 interacts with DENV-2 RNA Dependant RNA polymerase (RdRp) .
    Antiviral agent 51
  • HY-131083
    ε-Amanitin

    		DNA/RNA Synthesis ADC Cytotoxin Cancer
    ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II .
    ε-Amanitin
  • HY-155868
    5-Azacytidine 5′-triphosphate

    5-aza-CTP

    		 Others Others
    5-Azacytidine 5′-triphosphate (5-aza-CTP) is a cytidine analog that inhibitss the incorporation of [ 3H]CTP, but not [ 3H]UTP, into RNA in the DNA-dependent RNA polymerase reaction .
    5-Azacytidine 5′-triphosphate
  • HY-155868A
    5-Azacytidine 5′-triphosphate sodium

    5-aza-CTP sodium

    		 Others Others
    5-Azacytidine 5’-triphosphate sodium is a cytidine analog. 5-Azacytidine 5’-triphosphate sodium inhibits the incorporation of [ 3H]CTP, but not [ 3H]UTP, into RNA in the DNA-dependent RNA polymerase reaction .
    5-Azacytidine 5′-triphosphate sodium
  • HY-150641
    CDK-IN-9

    		CDK Apoptosis DNA/RNA Synthesis Cancer
    CDK-IN-9 (compound 24) is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC50 values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II .
    CDK-IN-9
  • HY-151829
    Fmoc-L-Asn(EDA-N3)-OH

    		ADC Linker Others
    Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II .
    Fmoc-L-Asn(EDA-N3)-OH

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